Ronidazole Capsule

Ronidazole Capsules
Usage
Ronidazole capsules are a nitroimidazole antimicrobial agent used primarily in veterinary medicine, particularly for the treatment of protozoal infections in cats and birds.
They may be prescribed for:
• Feline trichomoniasis (caused by Tritrichomonas foetus)
• Protozoal infections in birds (e.g., Trichomonas gallinae)
• Other practitioner-directed protozoal infections
Compounded capsules are commonly used to allow accurate dosing for individual animals.

Dosage
Dosage should be determined by the prescribing veterinarian based on the animal’s species, weight, and clinical condition.
Typical dosing considerations include:
• Administered once or twice daily, depending on protocol
• Dose is typically weight-based
• Capsules may be given with or without food, although giving with food may improve tolerance
• Complete the full course of treatment as prescribed
Careful adherence to dosing is important to ensure effectiveness and reduce resistance.

Mechanisms of Action
Ronidazole is a nitroimidazole antimicrobial.
Its mechanisms include:
Formation of reactive metabolites
Ronidazole is reduced within anaerobic organisms to form reactive intermediates.
DNA damage
These metabolites interact with microbial DNA, causing strand breakage and inhibition of nucleic acid synthesis.
Selective toxicity
The drug primarily affects anaerobic protozoa and bacteria, sparing host cells.

Contraindications
Ronidazole should not be used in:
• Animals with hypersensitivity to ronidazole or other nitroimidazoles
• Pregnant animals, unless benefits outweigh risks
• Very young or debilitated animals without veterinary supervision

Precautions
Ronidazole should be used with caution in:
• Animals with hepatic impairment
• Situations where neurological sensitivity may be a concern
Additional considerations include:
• Potential side effects may include:
• Lethargy
• Reduced appetite
• Neurological signs (e.g., ataxia, tremors, seizures in rare cases)
• Neurotoxicity is dose-related and may be reversible upon discontinuation
• Avoid overdosing and ensure accurate weight-based dosing
• Care should be taken to minimise human exposure (e.g., wear gloves when handling capsules if advised)
Owners should seek veterinary advice if they notice neurological symptoms, severe lethargy, or worsening condition.

Storage
• Store below 25°C unless otherwise directed
• Keep capsules in a tightly closed container
• Protect from heat, moisture, and direct light
• Keep out of reach of children and animals
Follow the storage instructions provided on the dispensing label supplied by the pharmacy.