Progesterone Capsule

Progesterone Capsules
Usage
Progesterone capsules contain a bioidentical progestogen used to support hormonal balance in women. They are commonly prescribed as part of hormone replacement therapy (HRT) or for reproductive health conditions.
They may be prescribed for:
• Hormone replacement therapy (HRT) in combination with estrogen
• Endometrial protection in women with an intact uterus
• Menstrual cycle regulation
• Luteal phase support in fertility treatment
• Premenstrual syndrome (PMS) or PMDD (in selected cases)
• Other practitioner-directed uses in women’s health

Dosage
Dosage should be individualised and determined by the prescribing practitioner based on the indication and patient response.
Typical dosing considerations include:
• Usually administered once daily, often in the evening due to sedative effects
• May be used continuously or cyclically depending on treatment plan
• Capsules should be swallowed whole with water
• May be taken with or without food
Regular clinical review and monitoring are recommended.

Mechanisms of Action
Progesterone is a natural progestogen.
Its mechanisms include:
Endometrial transformation
Progesterone converts the endometrium from a proliferative to a secretory state, preparing it for implantation.
Regulation of hormonal balance
Balances the effects of estrogen and reduces the risk of endometrial hyperplasia.
Effects on reproductive system
Supports pregnancy maintenance and normal menstrual function.
Central nervous system effects
May have sedative and calming effects via interaction with GABA receptors.

Contraindications
Progesterone capsules should not be used in patients with:
• Hypersensitivity to progesterone or formulation components
• Known or suspected hormone-dependent cancers (e.g., breast cancer)
• Undiagnosed abnormal vaginal bleeding
• Active or history of thromboembolic disorders
• Severe liver disease

Precautions
Progesterone should be used with caution in patients with:
• Cardiovascular disease or risk factors
• History of thromboembolism
• Liver impairment
• Depression or mood disorders
Additional considerations include:
• May cause:
• Drowsiness or sedation
• Dizziness
• Breast tenderness
• Mood changes
• Use caution when driving or operating machinery
• Often used in combination with estrogen to reduce endometrial risk
• Regular monitoring and clinical review are recommended
Patients should seek medical advice if they experience unusual bleeding, chest pain, or mood changes.

Storage
• Store below 25°C unless otherwise directed
• Keep capsules in a tightly closed container
• Protect from heat, moisture, and direct light
• Keep out of reach of children and pets
Patients should follow the storage instructions provided on the dispensing label supplied by the pharmacy.