Prednisolone Capsule

Prednisolone Capsules
Usage
Prednisolone capsules are an oral corticosteroid used for their anti-inflammatory and immunosuppressive effects. They are widely prescribed for a variety of inflammatory, allergic, and autoimmune conditions.
They may be prescribed for:
• Allergic conditions (e.g., severe allergies, asthma exacerbations)
• Autoimmune diseases (e.g., rheumatoid arthritis, lupus)
• Inflammatory conditions (e.g., inflammatory bowel disease)
• Dermatological conditions
• Respiratory disorders
• Other practitioner-directed conditions requiring systemic corticosteroid therapy

Dosage
Dosage should be individualised and determined by the prescribing practitioner based on the condition and patient response.
Typical dosing considerations include:
• Usually administered once daily, often in the morning to mimic natural cortisol rhythms
• May be given as divided doses in certain conditions
• Dose is often started higher and gradually tapered
• Capsules should be taken with food to reduce gastrointestinal irritation
Patients should not stop abruptly without medical advice.

Mechanisms of Action
Prednisolone is a glucocorticoid that affects multiple inflammatory pathways.
Its mechanisms include:
Anti-inflammatory effects
Prednisolone inhibits the production of pro-inflammatory mediators such as prostaglandins and cytokines.
Immunosuppressive activity
It reduces activity of immune cells, including T-lymphocytes, decreasing immune responses.
Stabilisation of cell membranes
Helps reduce capillary permeability and tissue swelling.
Gene regulation
Prednisolone influences gene expression involved in inflammation and immune function.

Contraindications
Prednisolone should not be used in patients with:
• Hypersensitivity to prednisolone or formulation components
• Systemic fungal infections (unless treated)
• Conditions where corticosteroid use is contraindicated as determined by the practitioner

Precautions
Prednisolone should be used with caution in patients with:
• Diabetes mellitus
• Hypertension
• Osteoporosis
• Peptic ulcer disease
• Infections, as corticosteroids may mask symptoms
• Psychiatric conditions
• Hepatic or renal impairment
Additional considerations include:
• Long-term use may lead to:
• Adrenal suppression
• Weight gain
• Mood changes
• Increased infection risk
• Bone loss
• May interact with other medications (e.g., NSAIDs, immunosuppressants)
• Tapering is required after prolonged use to avoid withdrawal symptoms
Patients should seek medical advice if they experience fever, mood changes, vision problems, or unusual swelling.

Storage
• Store below 25°C unless otherwise directed
• Keep capsules in a tightly closed container
• Protect from heat, moisture, and direct light
• Keep out of reach of children and pets
Patients should follow the storage instructions provided on the dispensing label supplied by the pharmacy.