DHEA Capsule

DHEA (Dehydroepiandrosterone) Capsules
Usage
DHEA capsules are an oral formulation of a steroid hormone precursor used to support hormonal balance in patients with low DHEA levels or related endocrine conditions. DHEA is naturally produced by the adrenal glands and serves as a precursor to both androgens and estrogens.
It may be prescribed for:
• Adrenal insufficiency or low DHEA levels
• Age-related hormonal decline
• Fatigue and reduced wellbeing associated with hormonal imbalance
• Low libido and sexual dysfunction
• Support in certain endocrine or menopausal conditions under medical supervision
Use should be guided by a qualified healthcare professional, often with hormone level monitoring.

Dosage
Dosage should be individualised and determined by the prescribing practitioner based on clinical need and, where appropriate, laboratory results.
Typical dosing considerations include:
• Administered once daily, often in the morning to align with natural hormone rhythms
• Capsules should be swallowed whole with water
• May be taken with or without food
Regular review and adjustment may be required based on response and hormone levels.

Mechanisms of Action
DHEA is a prohormone involved in the synthesis of multiple steroid hormones.
Its mechanisms include:
Conversion to androgens and estrogens
DHEA is metabolised into testosterone, estrogen, and other steroid hormones, depending on tissue-specific pathways.
Support of endocrine balance
By serving as a precursor, DHEA helps maintain hormonal equilibrium across multiple systems.
Effects on mood, energy, and libido
Through its conversion to active hormones, DHEA may influence energy levels, mood, and sexual function.
Potential neurosteroid activity
DHEA may also have roles in central nervous system function, including cognition and stress response.

Contraindications
DHEA capsules should not be used in patients with:
• Hypersensitivity to DHEA or any component of the formulation
• Hormone-sensitive cancers (e.g., breast, prostate, endometrial cancer) unless under specialist supervision
• Pregnancy or breastfeeding

Precautions
DHEA should be used with caution in patients with:
• Endocrine disorders
• History of hormone-sensitive conditions
• Liver disease
• Cardiovascular risk factors
Additional considerations include:
• Hormone levels may require monitoring during therapy
• Excess dosing may lead to androgenic side effects, such as:
• Acne
• Hair growth (hirsutism)
• Voice changes
• May affect lipid profiles and insulin sensitivity
• Avoid combining with other hormone therapies unless directed by a healthcare professional
Patients should seek medical advice if they experience unusual hormonal symptoms, mood changes, or adverse effects.

Storage
• Store below 25°C unless otherwise directed
• Keep capsules in a tightly closed container
• Protect from heat, moisture, and direct light
• Keep out of reach of children and pets
Patients should follow the storage instructions provided on the dispensing label supplied by the pharmacy.