Vit B1+ Vit B2 (Riboflavin 5 Phosphate)+ Vit + Vit B5 (B Complex)

Vit B1+ Vit B2 (Riboflavin 5 Phosphate)+ Vit + Vit B5 (B Complex)

Available presentation(s): 10, 50 mL. Verify the exact concentration and total active quantity on the prescription and dispensing label.

Introduction: A compounded B-complex combination containing thiamine, riboflavin-5-phosphate, niacin and pantothenic acid. It has no universal parenteral wellness regimen.

Dosage: Prescribe exact volume and component doses, route, frequency and duration. Confirm whether vitamin B3 is nicotinamide or nicotinic acid, as safety profiles differ. Use for a documented need when oral therapy or an approved product is unsuitable.

Mechanisms of Action: Provides coenzymes for carbohydrate, amino-acid and lipid metabolism, redox reactions, methylation and haematopoiesis. Benefit is most plausible when deficiency or increased requirement is present.

Contraindications & Precautions: Avoid in hypersensitivity. Parenteral thiamine can cause anaphylaxis; high cumulative B6 causes neuropathy; niacin forms can cause flushing, hypotension, hyperglycaemia, hyperuricaemia or hepatic injury. Methylcobalamin can rarely cause hypersensitivity.

Interactions: Pyridoxine reduces levodopa effect without carbidopa; chloramphenicol can blunt B12 response; fluorouracil affects thiamine; glucose-lowering and antihypertensive medicines may require review if niacin exposure is material.

Adverse Reactions / Side Effects: Injection-site pain, flushing, nausea, headache, dizziness, rash and hypersensitivity may occur. Serious but uncommon risks include anaphylaxis, hepatotoxicity (niacin), neuropathy (excess B6) and dosing errors.

Pregnancy & Breastfeeding: Correct documented deficiencies in pregnancy and breastfeeding, but avoid supraphysiologic combination dosing unless a specialist determines it is necessary.

Storage: Store under the conditions stated on the Optimus dispensing label and product-specific worksheet. Protect from light where labelled. Do not freeze unless explicitly validated. Maintain cold chain if the label requires refrigeration. Do not use after the assigned beyond-use date or if there is visible particulate matter, precipitation, colour change, loss of container integrity or evidence of improper storage. Once entered, follow the validated in-use time; do not assume a compounded vial is multi-dose.

References

• New Zealand Formulary (NZF), current online edition; product-specific approved data sheets where available; USP Pharmaceutical Compounding—Sterile Preparations; and Optimus Healthcare validated formulation, sterility/endotoxin controls and assigned beyond-use date.
• NIH Office of Dietary Supplements. Health Professional Fact Sheets (vitamins and minerals), current online editions. https://ods.od.nih.gov/factsheets/list-VitaminsMinerals/
• DailyMed. Thiamine Hydrochloride, Pyridoxine Hydrochloride, Hydroxocobalamin and Levocarnitine injection labels, current editions. https://dailymed.nlm.nih.gov/
• US FDA. Compounding and the FDA: Questions and Answers. Updated 16 September 2025. https://www.fda.gov/drugs/human-drug-compounding/compounding-and-fda-questions-and-answers